In the 12 years since the Human Genome Project was completed, biologists have linked more than a thousand regions of the genome to disease. “But in most cases, we don’t actually know how they function,” says Manolis Kellis, a computational biologist at Massachusetts Institute of Technology. Enter the epigenome. If the human genome is the book of life, the epigenome is the collection of bookmarks and highlighting that tells the cell what passages of the book to read.
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